邹邵敏(副研究员,硕士生导师)


主要围绕消化道肿瘤及并发症,探讨分子标志物及代谢重编程机制研究。近年来以第一作者/通讯作者(含共同)发表成果在Cancer Research、Nature Communications、J Am Chem SOC、CELL DEATH DIS 等期刊上。目前主持国家自然科学基金面上项目、青年项目等。

教育及工作经历:
2024-07 至今, 中山大学附属第六医院, 副研究员
2021-07至 2024-07, 中山大学附属第六医院,博士后
2016-09 至 2021-06, 中山大学附属第六医院, 分子医学(硕博连读), 医学博士
2010-09 至 2015-06, 广东医科大学, 医学检验, 医学学士
代表性论文代表性项目荣誉
1.Shaomin Zou, Baifu Qin, Ziqing Yang, Wencong Wang, Jieping Zhang, Yijing Zhang, Manqi Meng, Junyan Feng, Yunling Xie, Ling Fang, Lishi Xiao, Peng Zhang, Xiangqi Meng, Hyun Ho Choi, Weijie Wen, Qihao Pan, Bart Ghesquière, Ping Lan*, Mong-Hong Lee*, Lekun Fang*. CSN6 Mediates Nucleotide Metabolism to Promote Tumor Development and Chemoresistance in Colorectal Cancer. Cancer research. 2023 Feb 3;83(3):414-427
2.Ziqing Yang#, Dandan Huang#, Manqi Meng#, Wencong Wang, Junyan Feng, Lekun Fang *, Honglei Chen*, Shaomin Zou*. BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation. Cell death & disease. 2022 Dec 16;13(12):1049
3.Shaomin Zou#, Dan Zhong#, Song Xiang#, Jieping Zhang, Ruijia Zhang, Ziqing Yang, Manqi Meng, Kuiheng Chen, Ling Fang, Bart Ghesquiere, Hai-Tao Feng*, Ben Zhong Tang*, Lekun Fang*. AIEgen targets the STAT3-SUCLG2 axis to regulate metabolism for colorectal cancer theranostics. Aggregate. 2026 Jun 7;7(6)
4.Shaomin Zou#,Yizhi Huang#, Ziqing Yang, Jieping Zhang,Manqi Meng,Yijing Zhang, Junyan Feng, Rui Sun, Weiyao Li, Wencong Wang, Jesús García-Foncillas López, Lekun Fang. NSUN2 promotes colorectal cancer progression by enhancing SKIL mRNA stabilization. Clinical and Translational Medicine. 2024 Mar;14(3): e1621
5.Shaomin Zou#,Chao Yang#,Jieping Zhang#,Dan Zhong,Manqi Meng,Lu Zhang,Honglei Chen*, Lekun Fang*. Multi-omic profiling reveals associations between the gut microbiome, host genome and transcriptome in patients with colorectal cancer. Journal of Translational Medicine. 2024 Feb 18;22(1):175
6.Ziqing Yang#, Shaomin Zou#, Yijing Zhang, Jieping Zhang, Peng Zhang, Lishi Xiao, Yunling Xie, Manqi Meng, Junyan Feng, Liang Kang*, Mong-Hong Lee*, Lekun Fang*. ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis. Nature communications. 2023 Jul 13;14(1):4193
7.Hai-Tao Feng#, Shaomin Zou#, Ming Chen, Feng Xiong, Mong-Hong Lee, Lekun Fang*, Ben Zhong Tang*. Tuning Push-Pull Electronic Effects of AIEgens to Boost Theranostic Efficacy for Colon Cancer. Journal of American Chemical Society. 2020 Jul 1;142(26):11442-11450
8.Baifu Qin#, Shaomin Zou#, Kai Li#, Huashe Wang, Wenxia Wei, Boyu Zhang, Lishi Xiao, Hyun Ho Choi, Qin Tang, Dandan Huang, Qingxin Liu, Qihao Pan, Manqi Meng, Lekun Fang*, Mong-Hong Lee*. CSN6-TRIM21 axis instigates cancer stemness during tumorigenesis. British Journal of Cancer. 2020 May;122(11):1673-1685
9.Jieping Zhang#, Shaomin Zou#, Yijing Zhang#, Ziqing Yang, Wencong Wang, Manqi Meng, Junyan Feng, Peng Zhang, Lishi Xiao, Mong-Hong Lee*, Lekun Fang*. 3,3'-Diindolylmethane Enhances Fluorouracil Sensitivity via Inhibition of Pyrimidine Metabolism in Colorectal Cancer. Metabolites. 2022 Apr 30;12(5):410
10.Jieping Zhang#, Shaomin Zou#, Lekun Fang. Metabolic reprogramming in colorectal cancer: regulatory networks and therapy. Cell and Bioscience. 2023 Feb 8;13(1):25
11.Shaomin Zou#, Lekun Fang#, Mong-Hong Lee. Dysbiosis of gut microbiota in promoting the development of colorectal cancer. Gastroenterol Rep (Oxf). 2018 Feb;6(1):1-12