朱立新(副研究员,博士生导师)

研究方向:

消化道疾病的基础和转化研究,相关疾病包括炎症性肠病、脂肪肝、肥胖、代谢综合症、胃酸相关疾病、肠易激综合征和便秘。2010年开始从事疾病相关的肠道菌群研究,率先发表了肠道菌群在非酒精性脂肪肝病理发生发展中的作用,以第一兼通讯作者发表在Hepatology(IF=15, 单篇他引超过1000次)。朱博士还率先发表了便秘病人肠道菌群结构功能的变化。有关菌群研究的代表性成果第一或通讯作者发表在Nature Communications、Hepatology (两篇)、Gut(IF =19,两篇)等高影响力期刊。其他第一或通讯作者论文发表在Lancet Gastroenterology & Hepatology(两篇)、Journal of Pathology 等杂志。多次受邀在国际会议和研究机构作主旨演讲。


教育经历:

1991/09–1995/07,南开大学,生物化学与分子生物学系,学士

1995/09–2001/08,中国科学院上海生物化学研究所,博士

研究经历:

1999/5–2000/10,德国国家环境与健康研究中心分子病毒研究所,访问学者

2001/8-2002/8,中国科学院上海生化与细胞研究所,助理研究员

2002/8-2009/2,加州大学伯克利,细胞和分子生物学系,博士后

2009/2-2018/10,纽约州立大学布法罗分校,消化病和营养中心,助理教授,实验室主任;纽约州立大学基因组-环境-菌群卓越研究中心PI

2018/10-至今,中山大学百人计划副研究员,博士生导师


代表性论文代表性项目荣誉

疾病相关的肠道菌群研究论文

Yuanqi Wu#, Na Jiao#, Ruixin Zhu*, Yida Zhang, Dingfeng Wu, An-Jun Wang, Sa Fang, Liwen Tao, Yichen Li, Sijing Cheng, Xiaosheng He, Ping Lan, Chuan Tian*, Ning-Ning Liu*, and Lixin Zhu*, 2021, Identification of microbial markers across populations in early detection of colorectal cancer. Nature Communications, Accepted. (IF12)

Na Jiao, Susan S. Baker, Adrian Chapa-Rodriguez, Wensheng Liu, Colleen A. Nugent, Maria Tsompana, Lucy Mastrandrea, Michael J. Buck, Robert D. Baker, Robert J. Genco, Ruixin Zhu, Lixin Zhu*, 2018, Suppressed hepatic bile acid signaling despite elevated production of primary and secondary bile acids in NAFLD. Gut, 67(10):1881-1891. (IF20)

Ling Zhao, Yufen Huang, Lin Lu, Wei Yang, Tao Huang, Zesi Lin, Cheng-yuan Lin, Xiao-dong Fang, Lixin Zhu* and Zhaoxiang Bian*, 2018, Saturated long chain fatty acid-producing bacteria contribute to enhanced colonic motility in rats, Microbiome, 6(1):107. (IF11)

Na Jiao, Susan Baker, Colleen Nugent, Maria Tsompana, LitingCai, Yong Wang, Michael Buck, Robert Genco, Robert Baker, Ruixin Zhu, and Lixin Zhu*, 2018, Gut microbiome may contribute to insulin resistance and systemic inflammation in obese rodents: a meta-analysis. Physiological genomics, 50(4):244-254. (IF3, official journal of American Physiological Society)

Selected for APSselect (http://apsselect.physiology.org/), a collection from the APS that showcases some of the best recently published articles in physiological research.

Lixin Zhu*, Susan S. Baker*, Chelsea Gill, Wensheng Liu, RazanAlkhouri¶, Robert D. Baker, Steven R. Gill, 2013, Characterization of the gut microbiome in non-alcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH, Hepatology, 57(2): 601-609. (IF15)

The second most highly cited article in Hepatology in 2013, cited 984 times as of March, 2021. Highlighted by Nature Reviews (http://www.ncbi.nlm.nih.gov/pubmed/23147655)

Lixin Zhu*, Wensheng Liu, RazanAlkhouri¶, Robert D. Baker, Jonathan E. Bard, Eamonn M. Quigley, and Susan S. Baker, 2014, Structural changes in the gut microbiome of constipated patients, Physiological Genomics, 46(18):679-86. (IF3, official journal of American Physiological Society) The first study addressing the gut microbiome in functional constipation. Cited 170 times as of March, 2021

新冠肺炎相关研究论文

Jingrong Weng#, Yichen Li#, Jie Li#, Lihan Shen#, Lixin Zhu#,*, Yufan Liang, Xutao Lin, Na Jiao, Sijing Cheng, Yibo Huang, Yifeng Zou*, Guangjun Yan*, Ruixin Zhu*, Ping Lan, 2021, Gastrointestinal sequelae in patients 90 days after discharge for COVID-19. Lancet Gastroenterology & Hepatology, Accepted. (IF15)

Yunle Wan#, Jie Li#, Lihan Shen#, Yifeng Zou#, Linlin Hou#, Lixin Zhu#*, Howard S. Faden, Zhipeng Tang, Mang Shi, Na Jiao, Yichen Li, Sijing Cheng, Yibo Huang, Dingfeng Wu, Zhifeng Xu, Linnuo Pan, Jun Zhu, Guangjun Yan*, Ruixin Zhu*, Ping Lan*, 2020, Enteric involvement in hospitalised COVID-19 patients outside Wuhan, China. Lancet Gastroenterology & Hepatology, 5(6):534-535. (IF15)

Yichen Li#; Na Jiao#; Lixin Zhu#,*; Sijing Cheng, Ruixin Zhu*; Ping Lan*, 2020, Non-febrile COVID-19 patients were common and often became critically ill: a retrospective multicenter cohort study. Critical Care, accepted. #co-first authors; *co-correspondence authors. (IF 6.6)

 

消化道疾病相关论文

Ruixin Zhu, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu¶, Weili Lin¶, Wensheng Liu, Robert D. Baker, Sugantha Govindarajan, Zhiwei Cao, Patrizia Farci, Anna Mae Diehl, Lixin Zhu*, 2016, Systematic Analysis of NAFLD Transcriptome Revealed Elevated Expression of Alcohol Metabolizing Genes in NAFLD Livers, Journal of Pathology. 238:531-542. (IF 6)

Lili Yang, Shijie Tang, Susan S. Baker, Ingrid Arijs, Wensheng Liu, Razan Alkhouri, Ping Lan, Robert D. Baker, Zhipeng Tang,Guang Ji, Paul Rutgeerts, Severine Vermeire, Ruixin Zhu, Lixin Zhu*, 2019, Difference in pathomechanism between Crohn’s disease and ulcerative colitis revealed by colon transcriptome. Inflammatory Bowel Diseases, 25(4):722-731. (IF 4.2)

 

受邀综述

Lixin Zhu*, Robert D. Baker, Ruixin Zhu, Susan S. Baker, 2017, Sequencing the gut metagenome as a non-invasive diagnosis for advanced nonalcoholic steatohepatitis. Hepatology, 66(6): 2080-2083. (IF15)

Lixin Zhu*, Robert D. Baker, Ruixin Zhu, Susan S. Baker, 2016, Gut microbiota produce alcohol and contribute to NAFLD, Gut, 65:1232. (IF20)

John. G. Forte* and Lixin Zhu*. 2010, Apical recycling of the gastric parietal cell H-K-ATPase, Annual Review of Physiology, 72: 273-296. (IF20)