杨孜欢 (副研究员,博士生导师 )

       副研究员,分子医学、医学(检验)技术博士生导师。现任中山大学胃肠病学研究所(广东省结直肠盆底疾病研究重点实验室)副所长、中山大学附属第六医院检验科副主任(主持工作)、高质量发展办公室副主任、分子医学教研室主任;曾任中山大学附属第六医院科学技术处处长。2008年获中山大学生理学博士学位,2008-2011年美国西雅图华盛顿大学检验医学系博士后,长期从事肿瘤标志物和肿瘤筛查诊治技术研发。第一或通讯作者发表SCI论文10余篇;主持国家自然科学基金面上项目、广东省自然科学基金等课题;国家重点研发计划、广东省重点研发计划等项目主要参与人;担任多个国际学术期刊审稿专家,中国抗癌协会肿瘤胃肠病学专委会委员、广东省临床医学学会检验医学专委会副主任委员
等学术任职;
授权发明专利4项;2016年国家科技进步二等奖、2019年中华医学科技二等奖、2020年教育部科技进步一等奖等奖项主要完成人。

教育经历:

2003/09–2008/06,中山大学,生命科学学院,硕博连读,博士

1999/09–2003/06,湖南师范大学,生命科学学院,学士

研究工作经历:

2016/01-至今,中山大学,附属第六医院,副研究员

2011/11-2015/12,中山大学,附属第六医院,助理研究员

2008/12–2011/09,美国西雅图华盛顿大学,医学院,博士后


代表性论文代表性项目荣誉

1.Liu, Binbin; Liu, Tengfei; Liu, Yiting; Feng, Xingzhi; Jiang, Xuefei; Long, Jiahui; Ye, Shubiao; Chen, Daici; Wang, Jianping; Yang, Zihuan*; TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer, International Journal of Biological Sciences, 2022, 18(4): 1677-1694

2.Jiang, Xuefei; Yang, Lanlan; Gao, Qianling; Liu, Yiting; Feng, Xingzhi; Ye, Shubiao; Yang, Zihuan*; The Role of RAB GTPases and Its Potential in Predicting Immunotherapy Response and Prognosis in Colorectal Cancer, Frontiers in Genetics, 2022, 13: 828373

3.Liu, Tengfei #, Liu, Binbin #, Liu, Yiting, Feng, Xingzhi, Jiang, Xuefei, Long, Jiahui, Gao, Qianling, Yang, Zihuan*, Vesicle transporter GOLT1B mediates the cell membrane localization of DVL2 and PD-L2 and promotes colorectal cancer metastasis. Cancer Cell International. 2021; 21:287

4.Chen, Daici *#, Li, Yichen #, Zhang, Xiaowen #, Wu, Haiyong, Wang, Qian, Cai, Jian, Cui, Yanmei, Liu, Huanliang, Lan, Ping, Wang, Jianping, Yang, Zihuan*, Wang, Lei*, Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation. Oncogene. 2019;38(37):6429-44

5.Huang, Dandan(#), Feng, Xingzhi(#), Liu, Yiting, Deng, Yanhong, Chen, Hao, Chen, Daici, Fang, Lekun, Cai, Yue, Liu, Huanliang, Wang, Lei, Wang, Jianping(*), Yang, Zihuan(*). AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer. Cell death & disease. 2017;8(6):e2894. doi: 10.1038/cddis.2017.282. 

6.Fang, Lekun (#),Yang, Zihuan(#),Zhou, Junyi,Tung, Jung-Yu,Hsiao, Chwan-Deng,Wang, Lei,Deng, Yanhong,Wang, Puning,Wang, Jianping(*),Lee, Mong-Hong(*),Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer.,Molecular Cancer Therapeutics. 2015;14(6):1476-87

7.Yang, Zihuan(#),Huang, Dandan,Fang, Lekun,Feng, Xingzhi,Liu, Huanliang,Wang, Lei, Wang, Jianping(*),Predicting adjuvant chemotherapy outcome by simultaneous analysis of thymidylate synthase expression and p53 nuclear accumulation in colorectal cancer,Journal of Cancer Therapy,2015,6(5):446-454

8.Yang, Zihuan(#)(*),Pan, Ao,Zuo, Wulin,Guo, Jinghui,Zhou, Wenliang(*),Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle.,Journal of Ethnopharmacology,2014,155(2):1177-1183

9.Yang, Zi-Huan(#),Yu, Hai-Jie (#),Pan, Ao,Du, Jian-Yang,Ruan,Ye-Chun,Ko, Wing-Hung,Chan, Hsiao-Chang(*),Zhou, Wen-Liang(*),Cellular Mechanisms Underlying the Laxative Effect of Flavonol Naringenin on Rat Constipation Model,PLoS One,2008,3(10)

10.Yang, Zi-Huan(#),Pan, Ao,Ruan, Ye-Chun,Yu, Hai-Jie,Wu, Zhong-Luan,Xiang, Hui,Zhou, Wen-Liang(*),Cellular mechanism of adrenalin stimulated chloride secretion via beta-adrenoceptor in T84 cells,Cell Biology International,2008,32(6):679-687

11.杨孜欢(#)(*),冯杏芝,方乐堃,黄丹丹,汪建平(*),长链非编码 RNA

MALAT1调控 Rac1b表达与结直肠癌侵袭和转移的关系,中国病理生理杂志,2015,31(8):1417-1421

12.杨孜欢(#), 潘奥, 陈思亮, 周文良。麻仁软胶囊在诱导大鼠结肠上皮细胞阴离子分泌中的作用。中药药理与临床,2008,24(4):1-5 

专利

1.杨孜欢; 刘腾飞; 刘彬彬; 冯杏芝; 刘依婷; 蒋雪飞 ; GOLT1B抑制剂在制备治疗结直肠癌药物中的应用, 2020-10-13, 中国, 202011087782.9 (发明专利)

2.杨孜欢; 刘彬彬; 刘腾飞; 冯杏芝; 刘依婷; 蒋雪飞 ; TSG-6基因在预测结直肠癌转移及预后方面的应用, 2020-10-29, 中国, 202011178863.X (发明专利)