孟祥祺(副研究员,博士生导师 )

研究方向:结直肠癌进展和转移的分子机制
2004年09月01日—2008年06月,中山大学,生命科学学院 理学学士
2008年09月01日—2013年06月,中山大学,肿瘤防治中心 理学博士
2017年06月01日—至今,中山大学附属第六医院,广东省胃肠病学研究所,副研究员
2013年09月01日—2017年03月31日,美国Van Andel 研究所博士后,承担/参与项目:成骨细胞(破骨细胞)特异性TGF-β信号通路在前列腺癌(乳腺癌)骨转移中的作用

代表性论文代表性项目荣誉

代表性文章(第一和通讯,含共同)
1. Roles of lncRNA LVBU in regulating urea cycle/polyamine synthesis axis to promote colorectal carcinoma progression. Oncogene,  (2022); published online EpubJul 29 (10.1038/s41388-022-02413-8).
2. Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway. British journal of cancer 125, 1420-1431 (2021); published online EpubNov (10.1038/s41416-021-01537-0).
3. Diabetes mellitus type 2 drives metabolic reprogramming to promote pancreatic cancer growth. Gastroenterology report 8, 261-276 (2020); published online EpubAug (10.1093/gastro/goaa018).
4. Loss of TGF-β signaling in osteoblasts increases basic-FGF and promotes prostate cancer bone metastasis. Cancer letters 418, 109-118 (2018); published online EpubApr 1 (10.1016/j.canlet.2018.01.018).
5. Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis. Oncogene 35, 2370-2378 (2016); published online EpubMay 5 (10.1038/onc.2015.297).
6. Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology 145, 426-436.e421-426 (2013); published online EpubAug (10.1053/j.gastro.2013.04.004).
7. Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. PloS one 8, e61679 (2013)10.1371/journal.pone.0061679).