吴小剑(教授,博士生导师)

吴小剑,教授,主任医师,博士生导师,中山大学附属第六医院院长,广东省胃肠病学研究所所长,胃肠肛门外科学部主任。主持国家863计划、国家国际科技合作专项等重大课题,相关研究成果在PNAS、Adv Sci、Nat Comm、Lancet Gastroenterol等国际知名期刊发表。牵头制定了《中国溃疡性结肠炎外 科治疗指南》、《克罗恩病肛瘘诊断与治疗专家共识意见》。担任国际癌症基因组ICGC-ARGO结直肠癌项目负责人、教育部生物医学大数据工程研究中心副主任、教育部外科智能器械工程研究中心副主任、广东省医师协会胃肠外科医师分会主任委员、广东省炎症性肠病精准诊疗工程技术研究中心主任、《中华胃肠外科杂志》副主编、《中华炎性肠病杂志》主编。致力于结直肠癌精准早筛体系建立、局部晚期结直肠癌与复杂炎症性肠病外科治疗、结直肠癌复发耐药领域的基础与临床转化等研究。
教育经历:
1993.9-1998.6 海南医学院 本科
1999.9-2002.6 中山大学 硕士
2005.9-2008.6 中山大学 博士
2006.5-2007.6 美国哈佛大学麻省总医院 博士后
代表性论文代表性项目荣誉
1.Feng Gao, Jun-Xiang Ding, Bao-Wen Gai, Du Cai, Chu-Ling Hu, Feng-Ao Wang, Rui-Kun He, Junwei Liu*, Yi-Xue Li*, Xiao-Jian Wu *. Interpretable Multimodal Fusion Model for Bridged Histology and Genomics Survival Prediction in Pan-Cancer. Advanced Science. 2025;12(17):e2407060.
2.Zhao-Liang Yu#, Peng Deng#, Yu-Feng Chen#, De-Zheng Lin, Shini Liu, Jinghan Hong, Pei-Yong Guan, Jian-Feng Chen, Min-Er Zhong, Jing-Hong Chen, Xiao-Chuan Chen, Yi-Chen Sun, Ya-Li Wang, Pei-Li Wang, Ze-Rong Cai, Jason Yongsheng Chan, Yu-Lin Huang, Rong Xiao, Yao-Yu Guo, Xian Zeng, Wen-Yu Wang, Yi-Feng Zou, Qiang Yu, Ping Lan, Bin Tean Teh, Xiao-Jian Wu*, Jing Tan*. Pharmacological modulation of RB1 activity mitigates resistance to neoadjuvant chemotherapy in locally advanced rectal cancer. Proc Natl Acad Sci U S A . 2024 Feb 6;121(6):e2304619121.
3.Feng Gao#∗, Min-Hao Hu#, Min-Er Zhong#, Shi-Xiang Feng#, Xu-Wei Tian#, Xiao-Chun Meng#, Ma-Yi-Di-Li Ni-Jia-Ti, Ze-Ping Huang, Min-Yi Lv, Tao Song,Xiao-Fan Zhang*, Xiao-Guang Zou*, Xiao-Jian Wu*, Segmentation only uses sparse annotations: Unified weakly and semi-supervised learning in medical images. Medical Image Analysis. 2022 Aug: 80:102515.
4.Zhao-Liang Yu#, Peng Deng#, Yu-Feng Chen#, Shi-Ni Liu, Jinghong Chen, Zi-Huan Yang, Jian-Feng Chen, Xin-Juan Fan, Pei-Li Wang, Ze-Rong Cai, Ya-Li Wang, Pei-Shan Hu, De-Zheng Lin, Rong Xiao, Yi-Feng Zou, Yan Huang, Qiang Yu, Ping Lan*, Jing Tan*, Xiao-Jian Wu*. Inhibition of the PLK1-Coupled Cell Cycle Machinery Overcomes Resistance to Oxaliplatin in Colorectal Cancer. Advanced Science. 2021 Dec;8(23): e2100759.
5.Bei-Ping Zhong#, Bing Cheng#, Xiao-Ming Huang, Qian Xiao, Zhi-Tong Niu, Yu-feng Chen, Qiang Yu*, Wen-Yu Wang*, Xiao-Jian Wu*. Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling. Cell Death and Disease. 2021 Dec 20;13(1):16.