杨孜欢 (研究员,博士生导师)

中山大学附属第六医院院长助理、临床检验科主任

广东省胃肠病学研究所(中山大学胃肠病学研究所)副所长

中国抗癌协会肿瘤标志专委会常务委员

广东省医学会精准医学和分子诊断学分会 副主任委员

广东省医学会微生态医学分会 副主任委员

广东省抗癌协会肿瘤标志专委会 副主任委员


  杨孜欢研究员,博士生导师,博士后合作导师。主要研究领域为胃肠道疾病的基础和转化研究、病原微生物感染诊断新技术研发。以第一或通讯作者在Science Translational Medicine,Cancer Letters,NPJ Precis Oncol 等杂志上发表论文 20 余篇;主持国家自然科学基金、广东省自然科学基金、广州市重点研发项目等课题; 作为主要完成人获得2016年国家科技进步二等奖、2019年中华医学科技奖、2020年教育部科技进步一等奖、2024年广东省科技进步一等奖。


主要研究方向

(1)胃肠道疾病的基础和转化研究

(2)病原微生物感染诊断新技术研发




代表性论文代表性项目荣誉

1.Gao Qianling, Yang Lanan, Ye Shubiao, Mai Mingru, Liu Yiting, Jiang Xuefei, Feng Xingzhi, Yang Zihuan*. Targeting SlRT2 induces MLH1 deficiency and boosts antitumor immunity in preclinical colorectal cancer models. Science Translational Medicine. 2025 Jul 16;17(807):eadv0766.(IF:15.6)
2.Du Cai,  Mingru Mai,  Rende Huang,  Haoning Qi,  Xingzhi Feng,  Qianling Gao,  Yinmeng Zhang,  Chenghang Li,  Xiaojian Wu*,  Yize Mao*,  Zihuan Yang*,  Feng Gao*. Decoding Senescence-Driven Heterogeneity in Early-Onset Colorectal Cancer for Prognostic and Therapeutic Stratification, Cancer Science, 2025: 1–18(IF:4.9)
3.Jiang Xuefei, Yang Lanan, Chen Guanxing, Feng Xingzhi, Liu Yiting, Gao Qianling, Mai Mingru, Chen Calvin Yu-chian, Ye Shubiao, Yang Zihuan*. Discovery of Kinetin in inhibiting colorectal cancer progression via enhancing PSMB1-mediated RAB34 degradation. Cancer Letters. 2024 Mar 1;584:216600.(IF:11.8)
4.Shi Mengchen; Ye Linsen; Zhao Lu; He Lingyuan; Chen Junxiong; Zhang Jingdan; Su Yixi; Dong Haiyan; Liu Jiaqi; Liang Liumei; Zheng Wenwen; Xiao Yanhong; Liu Huanliang*; Yang Xiangling*; Yang Zihuan *; Tumor derived exosomal ENTPD2 impair CD8+ T cell function in colon cancer through ATP-adenosine metabolism reprogramming. Cell Communication and Signaling. 2024 May 16;22(1):274(IF:11.6) 
5.Ye SB, Cheng YK, Li PS, Zhang L, Zhang LH, Huang Y, Chen P, Wang Y, Wang C, Peng JH, Shi LS, Ling L, Wu XJ*, Qin J*, Yang Zihuan*, Lan P*. High-throughput proteomics profiling-derived signature associated with chemotherapy response and survival for stage II/III colorectal cancer. NPJ Precision Oncology. 2023; May 31;7(1):50. (IF:9.9)
6.Liu Yiting, Gao, Qianling, Feng Xingzhi, Chen Guanxing, Jiang Xuefei, Chen Daici, Yang Zihuan*. Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt/beta-catenin signaling activation. Gastroenterology Report (Oxf). 2023;11:goad033. (中国科技期刊卓越行动计划梯队期刊,IF: 4.0)
7.Liu Binbin; Liu Tengfei; Liu Yiting; Feng Xingzhi; Jiang Xuefei; Long, Jiahui; Ye Shubiao; Chen Daici; Wang, Jianping; Yang Zihuan*; TSG-6 promotes Cancer Cell aggressiveness in a CD44-Dependent Manner and Reprograms Normal Fibroblasts to create a Pro-metastatic Microenvironment in Colorectal Cancer, International Journal of Biological Science, 2022, 18(4): 1677-1694 (IF: 11.7)
8.Liu, Tengfei, Liu, Binbin, Liu Yiting, Feng Xingzhi, Jiang Xuefei, Long, Jiahui, Gao, Qianling, Yang Zihuan*, Vesicle transporter GOLT1B mediates the cell membrane localization of DVL2 and PD-L2 and promotes colorectal cancer metastasis. Cancer Cell International. 2021; 21:287 (IF: 7.0)
9.Chen Daici*, Li, Yichen, Zhang, Xiaowen, Wu, Haiyong, Wang, Qian, Cai, Jian, Cui, Yanmei, Liu, Huanliang, Lan, Ping, Wang, Jianping, Yang Zihuan*, Wang, Lei*, Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation. Oncogene. 2019;38 (37):6429-44 (IF: 9.1)
10.Huang Dandan, Feng Xingzhi, Liu Yiting, Deng Yanhong, Chen Hao, Chen Daici, Fang Lekun, Cai Yue, Liu Huanliang, Wang Lei, Wang Jianping*, Yang Zihuan*. AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer. Cell Death Disease. 2017;8(6):e2894. doi: 10.1038/cddis.2017.282 (IF: 12.2)