Hyun Ho Choi(Associate Professor)
91/03/01-95/02/25; B. Sc Korea University, South Korea
95/03/01-97/02/25; M.S Korea University, South Korea;
05/08/22-11/05/05; M. S University of Texas Health Science Center-MD And Cancer Center, U.S.A
12/01/17-14/05/09; Ph.D Texas A&M University , U.S.A
Research Experiences：
1996/12/03 – 1998/02/10 : Researcher. R&D Center, Crown Confectionery Co. Ltd, Seoul, Korea
1998/02/11 – 2002/07/19 : Research Fellow. Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
Project: 1) Impact of TGF- on the Rb mutant cervical cancer.
2) Anticarcinogenic effects of a novel ginseng metabolite on the myeloma cells
2014/06/11 – 2017/02/24 : Postdoctoral Fellow. Department of Cancer Biology,
The University of Texas MD Anderson Cancer Center, Houston, USA
Project: Impact of USP13 on the ovarian cancer metabolism
2017/03/01 - Current : Associate Professor. Research Institute of Gastroenterology, Sun Yat-sen University, Guangzhou, Guangdong, China
Representative papersResearch directionHonor
1.Han C*, Yang L*, Choi HH*, Baddour J, Achreja A, Liu Y, Li Y, Li J, Wan G, Huang C, Ji G, Zhang X, Nagrath D, Lu X. Amplification of USP13 drives ovarian tumor metabolism. Nature Communications. 2016 Nov 28;7:13525 equally contributed
2.Fang L, Lu W, Choi HH, Yeung SC, Tung JY, Hsiao CD, Fuentes-Mattei E, Menter D, Chen C, Wang L, Wang J, Lee MH. ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development. Cancer Cell. 2015 Aug 10;28(2):183-97.
3.Choi HH, Phan L, Chou PC, Su CH, Yeung SC, Chen JS, Lee MH. COP1 enhances ubiquitin-mediated degradation of p27Kip1 to promote cancer cell growth. Oncotarget. 2015 Aug 14;6(23):19721-34.
4.Choi HH, Guma S, Fang L, Phan L, Ivan C, Baggerly K, Sood A, Lee MH. Regulating the stability and localization of CDK inhibitor p27Kip1 via CSN6-COP1 axis. Cell Cycle. 2015 Jul 18;14(14):2265-73.
5.Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Jian C, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Dianna Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Yang W, Pusztai L, Yeung SC, Lee MH. The cell cycle regulator 14-3-3σ opposes cancer metabolic reprogramming by targeting c-Myc. Nature Communications. 2015 Jul 16;6:7530.
6.Choi HH and Lee MH. CSN6-COP1 axis in Cancer. Aging. 2015 Jul;7(7):461-462.
7.Choi HH, Su CH, Fang L, Zhang J, Yeung SC, Lee MH. CSN6 deregulation impairs genome integrity in a COP1-dependent pathway. Oncotarget. 2015 May 20;6(14):11779-93.
8.Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Choi HH, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. CSN6 drives carcinogenesis by positively regulating
9.Myc stability. Nature Communications. 2014 Nov 14;5:5384.Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN,
10.Pusztai L, Fraser Symmans W, Lee MH, Yeung SC. Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J. Natl cancer Inst. 2014 Jun 23;106(7)
11.Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, Yeung SC, Lee MH. HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle. 2012 Nov 15;11(22): 4181-90.
12.Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24)
13.Choi HH, Gully C, Su CH, Velazquez-Torres G, Chou PC, Tseng C, Zhao R, Phan L, Shaiken T, Chen J, Yeung SC, Lee MH. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ. Oncogene. 2011 Dec 1;30(48):4791-801
14.Choi S, Choi HH, Lee SH, Ko SH, You HJ, Ye SK, Chung MH. Anti-inflammatory effects of 8-hydroxy-2'-deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice. Free Radic Biol Med. 2007 Dec 15;43(12):1594-603.
15.Choi S, Choi HH, Choi J, Hyun J, Yoon B, Yeh S, Yoon S, Kim J, Yoo J, Chung M. Inhibitory effect of 8-oxo-7,8-dihydro-2'-deoxyguanosine on the growth of KG-1 myelosarcoma in Balb/c nude mice. Leuk Res. 2006 Nov;30(11):1425-36.
16.Yim HW, Jong HS, Kim TY, Choi HH, Kim SG, Song SH, Kim J, Ko SG, Lee JW, Kim TY, Bang YJ. Cyclooxygenase-2 inhibits novel ginseng metabolite-mediated apoptosis. Cancer Res. 2005 Mar 1;65(5):1952-60.
17.Choi HH, Jong HS, Park JH, Choi S, Lee JW, Kim TY, Otsuki T, Namba M, Bang YJ. A novel ginseng saponin metabolite induces apoptosis and down-regulates fibroblast growth factor receptor 3 in myeloma cells. Int J Oncol. 2003 Oct;23(4):1087-93.
18.Choi HH, Jong HS, Hyun Song S, You Kim T, Kyeong Kim N, and Bang YJ. p130 mediates TGF-beta-induced cell-cycle arrest in Rb mutant HT-3 cells. Gynecol Oncol. 2002 Aug;86(2):184-9.
19.Song SH, Jong HS, Choi HH, Inoue H, Tanabe T, Kim NK, and Bang YJ. Transcriptional silencing of Cyclooxygenase-2 by hyper-methylation of the 5' CpG island in human gastric carcinoma cells. Cancer Res. 2001 Jun 1;61(11):4628-35
20.Song SH, Jong HS, Choi HH, Kang SH, Ryu MH, Kim NK, Kim WH, and Bang YJ. Methylation of specific CpG sites in the promoter region could significantly down-regulate p16(INK4a) expression in gastric adenocarcinoma. Int J Cancer. 2000 Jul 15;87(2):236-40.
21.Kang SH, Choi HH, Kim SG, Jong HS, Kim NK, Kim SJ, and Bang YJ. Transcriptional inactivation of the tissue inhibitor of metalloproteinase-3 gene by dna hypermethylation of the 5'-CpG island in human gastric cancer cell lines. Int J Cancer. 2000 Jun 1;86(5):632-5
22.Kweon M.-H., Choi H.-H., and Yang H.-C. An anticoagulant polysaccharide isolated from the alkali extracts of Gyrophora esculenta. J. Indus. & Tech. Sci. 1: 81-93 (1998)
1. CSN6-mediated ubiquitination in cancer
2. Roles of USP13 in cancer
3. Impact of Helicobacter Pyroli in gastric cancer
Gene Depot Poster Award. 2015-Korean-American Bio-medical Scientists Symposium., Houston, Texas, USA, November. 14, 2015
