Daici Chen(Associate Professor)
2006.9–2012.4, McGill University, Biology, PhD
2003.9–2006.6, China Agricultural University, Plant Pathology, Master of Agriculture
1999.9–2003.6, South China Agricultural University, Plant Protection, Bachelor of Agriculture
Research Experience:
1. 2014.4-now, Sun Yat-sen University, Sixth Affiliated Hospital, Research Associate Professor, holds three provincial/city grants, participates in one national grant.
2. 2012.5-2014.3, IRIC, University of Montreal, post-doctoral research associate, participates in drug screen that targets ubiquitin-ubiquitin ligase complex.
Representative papersResearch directionHonor
1.Chen, D*. and J. Vogel, SAD kinase keeps centrosomes lonely. Nat Cell Biol, 2009. 11(9): p. 1047-8.
2.Keck, J. M.*, M. H. Jones*, C. C. Wong, J. Binkley, D. Chen, S. L. Jaspersen, E. P. Holinger, T. Xu, M. Niepel, M. P. Rout, J. Vogel, A. Sidow, J. R. Yates, 3rd, and M. Winey, A cell cycle phosphoproteome of the yeast centrosome. Science, 2011. 332(6037): p. 1557-61.
3.Hotz, M., C. Leisner, D. Chen, C. Manatschal, T. Wegleiter, J. Ouellet, D. Lindstrom, D. E. Gottschling, J. Vogel, and Y. Barral, Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation. Cell, 2012. 148(5): p. 958-72.
4.Chatr-Aryamontri, A., B. J. Breitkreutz, S. Heinicke, L. Boucher, A. Winter, C. Stark, J. Nixon, L. Ramage, N. Kolas, L. O'Donnell, T. Reguly, A. Breitkreutz, A. Sellam, D. Chen, C. Chang, J. Rust, M. Livstone, R. Oughtred, K. Dolinski, and M. Tyers, The BioGRID interaction database: 2013 update. Nucleic Acids Res, 2013. 41(Database issue): p. D816-23.
5.Ear, P. H., M. J. Booth, D. Abd-Rabbo, J. Kowarzyk Moreno, C. Hall, D. Chen, J. Vogel, and S. W. Michnick, Dissection of Cdk1-cyclin complexes in vivo. Proc Natl Acad Sci U S A, 2013. 110(39): p. 15716-21.
6.Chatr-Aryamontri, A., B. J. Breitkreutz, R. Oughtred, L. Boucher, S. Heinicke, D. Chen, C. Stark, A. Breitkreutz, N. Kolas, L. O'Donnell, T. Reguly, J. Nixon, L. Ramage, A. Winter, A. Sellam, C. Chang, J. Hirschman, C. Theesfeld, J. Rust, M. S. Livstone, K. Dolinski, and M. Tyers, The BioGRID interaction database: 2015 update. Nucleic Acids Res, 2015. 43(Database issue): p. D470-8.
7.Wen, C., J. Chen, D. Zhang, H. Wang, J. Che, Q. Qin, L. He, Z. Cai, M. Lin, Q. Lou, L. Huang, D. Chen, A. Iwamoto, D. Ren, L. Wang, P. Lan, J. Wang, H. Liu, and X. Yang, Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells. Cancer Lett, 2016. 383(2): p. 295-308.
8.Huang, D., X. Feng, Y. Liu, Y. Deng, H. Chen, D. Chen, L. Fang, Y. Cai, H. Liu, L. Wang, J. Wang and Z. Yang. "AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer." Cell Death Dis, 2017. 8(6): e2894.
9.Li, L., B. B. Ni, Q. H. Zhong, Y. H. Liu, M. H. Zhang, K. P. Zhang, D. C. Chen# and L. Wang#. "Investigation of correlation between mutational status in key EGFR signaling genes and prognosis of stage II colorectal cancer." Future Oncol, 2017. 13(17): 1473-1492.
10.Wu, P., L. Li, H. Wang, T. Ma, H. Wu, X. Fan, Z. Yang, D. Chen# and L. Wang# . "Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo." Dig Dis Sci. 2017
Function and mechanism of ubiquitin ligase in colorectal cancer development, hereditary gastrointestinal tumor, and biomarkers for radiation proctitis
One Hundred Talent Project, 2nd phase, Sun Yat-sen University
Guangdong “Thousand, Hundred, Ten” Project, university level
