Zihuan Yang( Associate Professor)
1999-2003, HUNAN NORMAL UNIVERSITY, B.S. in Biological Science
2003-2008, SUN YET-SEN UNIVERSITY, Ph.D. in Physiology
2008/12–2011/09 Senior Fellow, Department of Laboratory Medicine, University of Washington
2011/11-2015/12 Research associate, the 6th affiliated Hospital, Sun Yat-sen University
2016/01-Present Associate Professor, the 6th affiliated Hospital, Sun Yat-sen University
Representative papersResearch directionHonor
1.Huang D(#), Feng X(#), Liu Y, Deng Y, Chen H, Chen D, Fang L, Cai Y, Liu H, Wang L, Wang J(*), Yang Z(*). AQP9-induced cell cycle arrest is associated with RAS activation and improves chemotherapy treatment efficacy in colorectal cancer. Cell death & disease 2017, 8(6): e2894.
2.Fang L(#), Yang Z(#), Zhou J, Tung JY, Hsiao CD, Wang L, Deng Y, Wang P, Wang J(*), Lee MH(*). Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer. Molecular cancer therapeutics 2015, 14(6): 1476-1487.
3.Yang Z(#), Huang D, Fang L, Feng X, Liu H, Wang L. and Wang J(*). Predicting Adjuvant Chemotherapy Outcome by Simultaneous Analysis of Thymidylate Synthase Expression and p53 Nuclear Accumulation in Colorectal Cancer. Journal of Cancer Therapy 2015, 6(5): 446-454.
4.Yang Z(#)(*), Pan A, Zuo W, Guo J, Zhou W. Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle. Journal of Ethnopharmacology 2014, 155(2): 1177-1183.
5.Yang ZH(#), Yu HJ(#), Pan A, Du JY, Ruan YC, Ko WH, Chan HC(*), Zhou WL(*). Cellular mechanisms underlying the laxative effect of flavonol naringenin on rat constipation model. PLoS One 2008, 3(10): e3348.
6.Yang ZH(#), Pan A, Ruan YC, Yu HJ, Wu ZL, Xiang H, Zhou WL(*). Cellular mechanism of adrenalin stimulated chloride secretion via beta-adrenoceptor in T84 cells. Cell Biol Int 2008, 32(6): 679-687.
7.Zhang J(#), Wang X, de Voer RM, Hehir-Kwa JY, Kamping EJ, Weren RDA, Nelen M, Hoischen A, Ligtenberg MJL, Hoogerbrugge N, Yang X, Yang Z, Fan X, Wang L, Liu H, Wang J, Kuiper RP, van Kessel AG. A molecular inversion probe-based next-generation sequencing panel to detect germline mutations in Chinese early-onset colorectal cancer patients. Oncotarget 2017, 8(15): 24533-24547.
8.Xie M(#), Qin H, Luo Q, Huang Q, He X, Yang Z, Lan P(*), Lian L(*). MicroRNA-30a regulates cell proliferation and tumor growth of colorectal cancer by targeting CD73. BMC cancer 2017, 17(1): 305.
9.Wu P(#), Li L, Wang H, Ma T, Wu H, Fan X, Yang Z, Chen D(*), Wang L(*). Role of Angiogenesis in Chronic Radiation Proctitis: New Evidence Favoring Inhibition of Angiogenesis Ex Vivo. Digestive diseases and sciences 2017.
10.Yuan Z(#), Yu X, Ni B, Chen D, Yang Z, Huang J, Wang J, Chen D, Wang L. Overexpression of long non-coding RNA-CTD903 inhibits colorectal cancer invasion and migration by repressing Wnt/beta-catenin signaling and predicts favorable prognosis. Int J Oncol 2016, 48(6): 2675-2685.
11.Yu HC(#), Luo YX, Peng H, Wang XL, Yang ZH, Huang MJ, Kang L, Wang L, Wang JP(*). Association of perioperative blood pressure with long-term survival in rectal cancer patients. Chinese journal of cancer 2016, 35: 38.
12.Cao QH(#), Liu F, Yang ZL, Fu XH, Yang ZH, Liu Q, Wang L, Wan XB, Fan XJ(*). Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer. American journal of translational research 2016, 8(9): 3831-3847.
13.Xie M(#), Zhu J, He X, Yang Z, Chen X, Lan P, Lian L(*). Liver Metastasis from Colorectal Cancer in the Elderly: Is Surgery Justified? Digestive diseases and sciences 2015, 60(12): 3525-3535.
14.Yang Z(#), Chen H, Huo L, Yang Z, Bai Y, Fan X, Ni B, Fang L, Hu J, Peng J, Wang L, Wang J(*). Epigenetic inactivation and tumor-suppressor behavior of NGFR in human colorectal cancer. Molecular cancer research: MCR 2015, 13(1): 107-119.
15.Deng Y(#), Cai Y, Huang Y, Yang Z, Bai Y, Liu Y, Deng X, Wang J(*). High SLFN11 expression predicts better survival for patients with KRAS exon 2 wild type colorectal cancer after treated with adjuvant oxaliplatin-based treatment. BMC cancer 2015, 15: 833.
16.Ni BB(#), Yu XH, Guo XY, Fan XJ, Yang ZH, Wu PH, Yuan ZX, Deng YH, Wang JP, Chen DK, Wang L. Increased urothelial cancer associated 1 is associated with tumor proliferation and metastasis and predicts poor prognosis in colorectal cancer. Int J Oncol 2015, 47(4): 1329-1338.
17.Yang Z(#), Bai Y, Huo L, Chen H, Huang J, Li J, Fan X, Yang Z, Wang L, Wang J(*). Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer. BMC cancer 2014, 14: 568.
18.Wang T(#), Xu Y(#), Zhu H, Andrus T, Ivanov SB, Pan C, Dolores J, Dann GC, Zhou M, Forte D, Yang Z, Holte S, Corey L, Zhu T(*). Successful isolation of infectious and high titer human monocyte-derived HIV-1 from two subjects with discontinued therapy. PLoS One 2013, 8(5): e65071.
19.Yu H(#), Chen S, Yang Z, Pan A, Zhang G, Shan J, Tang X, Zhou W(*). Trimethyltin chloride induced chloride secretion across rat distal colon. Cell Biol Int 2010, 34(1): 99-108.
20.Du JY(#), Zuo WL, Ruan YC, Yang ZH, Chen MH, Chen SL, Li S, Wu ZL, Xiang H, Zhou WL(*). Stimulating effects of dopamine on chloride transport across the rat caudal epididymal epithelium in culture. Biol Reprod 2009, 80(1): 13-23.
21.Du JY(#), Ruan YC, Zuo WL, Yang ZH, Chen MH, Wu ZL, Xiang H, Zhou WL(*). Cellular mechanisms of carbachol-stimulated Cl- secretion in rat epididymal epithelium. Biol Reprod 2006, 75(3): 407-413.
Dr Yang’s research focus on basic and translational research on gastrointestinal (GI) diseases, which include developing molecular biomarkers that could predict GI cancer risk and chemotherapy sensitivity, and investigating the epithelial ion channel transport mechanisms and transmembrane signaling transduction of GI diseases by electrophysiological technique and molecular biology.
The second prize of 2016 National Science and Technology Progress Awards
