CHINESE

Tao Zuo(Professor)

Dr. Tao Zuo is a professor at Sun Yat-Sen University and the Sixth affiliated Hospital of SYSU. His research interests include gut microbiome in human health and disease, with special interest in microbiome ‘dark matters’ (virome/phageome, mycobiome, archaeaome) and their roles, interactions and mechanisms of actions in disease pathogenesis as well as therapeutics. He leads the Microbiome research Lab at SYSU Research Institute of Gastroenterology (Guangdong Institute of Gastroenterology), where he is also appointed as Associate Director.


Research interests:

Gut Microbiome in health and disease

Fecal Microbiota Transplantation

Inflammatory Bowel Disease

Website:www.zuotaolab.com

ORCID identifier: 0000-0001-8450-5281


Education and Academic Experiences

2018.11-2020.12.21  Research Assistant Professor 

Faculty of Medicine, The Chinese University of Hong Kong (CUHK)              

2019.11-2020.12.21  Scientist (Group Leader)  

Microbiome M@GIC center, Hong Kong              

2018.11-2020.12.21  Research Assistant Professor

 Center for Microbiota Research, CUHK              

2015.11-2018.11    Postdoc, Faculty of Medicine, CUHK

2014.8-2015.3      Visiting PhD

Boston Children’s Hospital, Harvard Medical School

2010.9-2015.6      PhD, Ocean University of China

2006.9-2010.6      Bachelor, Ocean University of China  


Representative papersResearch directionHonor

1.Tao Zuo#, Qin Liu#, Fen Zhang# et al. Depicting SARS-CoV-2 fecal viral activity in association with gut microbiota composition in patients with COVID-19. Gut (2020). (IF: 19.819, Journal Ranking: 1/145 in gastroenterology)

2.Tao Zuo#, Yang Sun#, Yating Wan et al. Human Gut DNA Virome Variations across Geography, Ethnicity, and Urbanisation. Cell Host & Microbe (2020). (IF: 15.923, Journal Ranking: 4/158 in microbiology)

3.Tao Zuo#, Fen Zhang# et al. Alterations in Gut Microbiota of Patients With COVID-19 During Time of Hospitalization. Gastroenterology (2020). https://doi.org/10.1053/j.gastro.2020.05.048. (IF: 17.373, Journal Ranking: 2/145 in gastroenterology)

4.Tao Zuo#, Hui Zhan# et al. Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalisation until Discharge. Gastroenterology (2020). (IF: 17.373, Journal Ranking: 2/145 in gastroenterology)

5.Tao Zuo, Siew C Ng et al. Gut mucosal virome alterations in ulcerative colitis. Gut (2019): gutjnl-2018. (IF: 19.819, Journal Ranking: 1/145 in gastroenterology)

6.Tao Zuo, Siew C Ng. Authors response: giant oversights in the human gut virome. Gut, gutjnl-2019. (2019)  (IF: 19.819, Journal Ranking: 1/145 in gastroenterology)

7.Tao Zuo, Michael A. Kamm, Jean-Frédéric Colombel, Siew C Ng. Urbanization and the gut microbiota in health and inflammatory bowel disease. Nature Reviews Gastroenterology & Hepatology, 2018, 1. doi:10.1038/s41575-018-0003-z. (IF: 29.848, Journal Ranking: 3/145 in gastroenterology)

8.Tao Zuo, Wong S H, Lam K, Siew C Ng et al. Bacteriophage transfer during faecal microbiota transplantation in Clostridium difficile infection is associated with treatment outcome. Gut, 2018, 67(4):634-643. (IF: 19.819, Journal Ranking: 1/145 in gastroenterology)

9.Tao Zuo, Sunny H Wong, Siew C Ng et al. Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection. Nature Communications, 2018, doi: 10.1038/s41467-018-06103-6. (IF: 12.121, Journal Ranking: 3/145 in Multidisplinary)

10.Fen Zhang#, Tao Zuo#, Yun Kit Yeoh#, et al. Longitudinal dynamics of gut bacteriome, mycobiome and virome after fecal microbiota transplantation in graft-versus-host disease. Nature Communications (IF: 12.121).

11.Yang Sun#, Tao Zuo#, et al. Population-level configurations of gut mycobiome across six ethnicities in urban and rural China. Gastroenterolgoy (IF: 17.373, , Journal Ranking: 2/145 in gastroenterology)

12.Yun Kit Yeoh#, Tao Zuo#, et al. Gut microbiota composition reflects disease severity and dysfunctional immune responses in COVID-19 patients. Gut (2020). (IF: 19.819, Journal Ranking: 1/145 in gastroenterology)

13.Tao Zuo#, Liu Q#, Zhang F#, et al. Temporal Landscape of Human Gut virome in SARS-CoV-2 infection and severity. Microbiome. (2021). In press. (IF: 11.607, Journal Ranking: 3/128 in Microbiology (medical))

14. Tao Zuo, Yun Kit Yeoh, Siew C Ng. Reply: The New Foe and Old Friends: Are We Ready for Microbiota-based Therapeutics in Treating COVID-19 Patients? Gastroenterolgoy (2021). (IF: 17.373, Journal Ranking: 2/145 in gastroenterology)

15.Tao Zuo, and Siew C. Ng. The gut microbiota in the pathogenesis and therapeutics of inflammatory bowel disease. Frontiers in microbiology 9 (2018). (IF: 4.235, Journal Ranking: 27/129 in gastroenterology)

16.Wu WKK^, Sun R^, Zuo T^, Tian Y^, Zheng Z, Ho J, Wu JCY, Chan FKL, Chan MTV, Yu J, Wong SH*, Wang MH*, Ng SC*. A novel susceptibility locus in MST1 and gene-gene interaction network for Crohn's disease in the Chinese. J Cell Mol Med, 2018, 22(4), 2368-2377. doi: 10.1111/jcmm.13530. (Co-first author) (IF:4.658, Journal Ranking: 38/175)

17.Tao Zuo, R Zhao, S LU, N Zhang, Q Zhang, C Xue. Novel dietary polysaccharide SIP promotes intestinal secretory immunoglobulin A secretion in mice under chemotherapy. Journal of functional foods. 2017,37, 379–389. (IF: 3.701, Journal Ranking: 41/327 in Food Science)

18.Zuo Tao, Zhang Na, Zhang Qi, et al. Transportation of squid ink polysaccharide SIP through intestinal epithelial cells and its utilization in the gastrointestinal tract. Journal of Functional Foods, 2016, 22: 408-416. (IF: 3.701, Journal Ranking: 41/327 in Food Science)

19.Tao Zuo, Lu Cao, Xuemin Li, Qi Zhang, Changhu Xue, Qingjuan Tang.  The squid ink polysaccharides protect tight junctions and adherens junctions from chemotherapeutic injury in the small intestinal epithelium of mice.  Nutrition and Cancer. 2015, 67.2:364-371. (IF: 2.322, Journal Ranking: 63/128 in Nutrition and Dietetics)

20.Tao Zuo, Xuemin Li, Yaoguang Chang, Gaofei Duan, Long Yu, Rong Zheng, Changhu Xue, Qingjuan Tang. Dietary fucoidan of Acaudina molpadioides and its enzymatic degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice. Food and Function. 2015,6, 415-422. (IF: 3.701, No. of citation: 5, Journal Ranking: 41/327 in Food Science) (IF: 4.171, Journal Ranking: 36/327 in Food Science)

21.Tao Zuo, Xinjia He, Lu Cao, Changhu Xue, Qingjuan Tang.  Dietary polysaccharide from Ommastrephes bartrami prevents chemotherapeutic mucositis by promoting the genes expression of antimicrobial peptides in paneth cells. Journal of functional foods. 2015, 12:530-539. (IF: 3.701, Journal Ranking: 41/327 in Food Science)

22.Tao Zuo, Lu Cao, Xuemin Li, Changhu Xue, Qingjuan Tang*.  Dietary squid ink polysaccharide induces goblet cells to protect small intestine from chemotherapy induced injury. Food and function, 2015, 6(3): 981-986. (IF: 4.171, Journal Ranking: 39/327 in Food Science)

23.Tao Zuo, Xianqi Feng, Na Zhang, Changhu Xue, Qing-Juan Tang*. Establishment of a functional secretory IgA transcytosis model system in vitro for functional food screening. J Applied Microbiology and Biotechnology. 2015, 6(3): 981-986. (IF: 3.670, Journal Ranking: 41/327 in Food Science)

24.Tao Zuo, Lu Cao, Xianghong Sun, Xuemin Li, Juan Wu, Shangyun Lu, Changhu Xue, and Qing-Juan Tang*. Dietary Squid Ink Polysaccharide Could Enhance Siga Secretion in Chemotherapeutic Mice. Food and Function. 2014, 5(12): 3189-3196. (IF: 4.171, Journal Ranking: 39/327 in Food Science)

25.Tao Zuo, Zhaojie Li, Yingchun Lv, Gaofei Duan, Chunxia Wang, Qingjuan Tang, Changhu Xue. Rapid identification of sea cucumber species with multiplex-PCR. Food control, 2012, 26(1):58-62. (IF: 4.258, Journal Ranking: 18/327 in Food Science)

26.Tang, Qingjuan1, Tao Zuo1, Shangyun Lu, Juan Wu, Jianghua Wang, Rong Zheng, Shiguo Chen, and Changhu Xue*. Dietary Squid Ink Polysaccharides Ameliorated the Intestinal Microflora Dysfunction in Mice Undergoing Chemotherapy. Food and function, 2014, 5 (10):2529-35. (IF: 4.171, Journal Ranking: 39/327 in Food Science)

27.Zuo T*. Unveiling the gut virome in human health and diseases. Int J Clin Virol. 2018; 2: 001-003

28.Tao Zuo*. The Changing Landscape of the Effect of food/diet on the gut Microbiota in Relation to Health and Disease. Nutrition and Food Toxicology, 2017, 2.1: 262-264

29.Zhang N, Ju Z, Zuo T*. Time for food: the impact of diet on gut microbiota and human health[J]. Nutrition, 2018. (IF:3.639)

30.Shangyun Lu and Tao Zuo*. Effect of Food Additives on the Gut Microbiome in Relation to Human Health. Nutrition and Food Toxicology 2.5 (2018): 474-476

31.Fen Zhang, Tao Zuo*. From Gut Microbial Ecogroup to Precision Nutrition and Human Health. Austin J Nutr Metab. 2019; 6(2): 1070

32.Hui Zhan, Tao Zuo*. Frontiers in human mycobiome in health and disease. American Journal of Biomedical Science & Research. 2020 - 7(4). AJBSR.MS.ID.001170. DOI:10.34297/AJBSR.2020.07.001170. 



International presentations:

1.Oral presentation: Digestive disease week, Chicago, USA; 2017

Microbiome & Microbial Diseases in the Gastrointestinal Tract, “Bacteriophage transfer during fecal microbiota transplantation is associated with treatment response in Clostridium difficile infection”

2.Oral presentation: Digestive disease week, Washington DC, USA; 2018

Distinguished microbiome plenary session, “Fecal microbiota transplantation alters the gut mycobiome (fungome) which correlates with treatment outcome in Clostridium difficile infections” 

3.Invited speaker: Microiome Science Days, Berchtesgaden, Germany; 2018

“Gut Fungi and Fecal microbiota transplantation” 

4.Oral presentation: Digestive disease week, San Diego, USA; 2019

IBD: Microbiome session, “Increased bacteriophage abundance and loss of viral-bacterial interactions in the mucosa of Ulcerative Colitis: Key to Pathogenesis?” 

5.Oral presentation: Digestive disease week, San Diego, USA; 2019 

Research Forum, Committee Sponsored Symposium; Presentation of Best of AGA (American Gastroenterological Association) at DDW in Chinese

6.Oral presentation: Digestive disease week, Chicago, USA; 2020 

Dark Matter: Nonbacterial Kingdoms of the Gut Microbiome, “The human gut virome is geography and ethnicity specific: population-based viral metagenomics across six ethnicities in rural and urban China” 

7.Invited speaker: Avison Symposium, Seoul, Korea; 2020

“Microbiome in Human Health”

8.Invited speaker: Targeting Microbiota 2021 Virtual Congress: October 22-23, 2021, France. International Society of Microbiota. 

Many aspects of the Gut microbiome in Patients With COVID-19.